A New Paradigm to Study Intestinal Bacterial Pathogens

Infections with many Gram-negative pathogens, including Escherichia coli, Salmonella, Shigella, and Yersinia, rely on the injection of effectors via type III secretion systems (T3SSs). The effectors hijack cellular processes through multiple mechanisms, including molecular mimicry and diverse enzymatic activities. Although in vitro analyses have shown that individual effectors can exhibit complementary, interdependent, or antagonistic relationships, most in vivo studies have focused on the contribution of single effectors to pathogenesis. By studying the T3SS effectors as robust intracellular networks, we can learn about the disease phenotypes and the adaptation to the host. We can also use genetic engineering to create improved study models of human-restricted infections.

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Organized by: Irene Sánchez Gavilán (Postdoctoral Researcher at Division of Preventive Medicine, Harvard Medical School)

Speaker: David Ruano Gallego (Ramón y Cajal Researcher - Autonomous University of Madrid, UAM)

Sponsor: RCCHU; Harvard University; UAM