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X-WR-CALNAME;VALUE=TEXT:Targeted Metabolic Profiling of (Poly)phenols Metabolites from Mediterranean Diet after Oral Administration in Brain, their Ability to Cross the Blood-Brain Barrier in Vivo and in Vitro, and their Anti-Inflammatory Activity in Brain Cells
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SUMMARY:Targeted Metabolic Profiling of (Poly)phenols Metabolites from Mediterranean Diet after Oral Administration in Brain, their Ability to Cross the Blood-Brain Barrier in Vivo and in Vitro, and their Anti-Inflammatory Activity in Brain Cells
DESCRIPTION:<p><span lang="EN-US" dir="ltr"><strong>Presentation Summary</strong></span></p><p class="text-align-justify"><span lang="EN-GB" dir="ltr">A Mediterranean diet rich in (poly)phenols has been associated with positive effects on neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases. However, its efficacy likely depends on its ability to reach the brain. We hypothesized that circulating phenolic metabolites derived from Mediterranean foods may cross the BBB, reaching the brain parenchyma, where they could attenuate neuroinflammation and help prevent neurodegenerative diseases. To address this, we analyzed the pharmacokinetic of (poly)phenols in the brain after oral administration of Mediterranean foods in Sprague Dawley rats by comparing perfused with non-perfused tissues, and validating their transport using an in vitro BBB model. Besides, the anti-neuroinflammatory effect of individual phenolic metabolites and physiologically representative mixtures was evaluated in human microglial cells (HMC3) stimulated by LPS or TNF-a. Our results confirm that circulating phenolic-derived metabolites after consuming (poly)phenol-rich extracts from Mediterranean foods crossed the BBB and reached the brain parenchyma, where they could attenuate neuroinflammation, potentially preventing or delaying the development of neurodegenerative diseases.</span></p><drupal-media data-entity-type="media" data-entity-uuid="547d7a3b-5d1d-4d52-846e-08b9d3770df3" data-align="center">&nbsp;</drupal-media><p class="text-align-justify">&nbsp;</p><p class="text-align-justify"><span lang="EN-US" dir="ltr"><strong>About&nbsp;Antonio González-Sarrías</strong></span><span lang="EN-US"></span></p><p class="text-align-justify"><span lang="EN-GB" dir="ltr">Antonio González-Sarrías is a Tenured Scientist at CEBAS-CSIC (Murcia, Spain) since 2018. He is a Biologist and obtained his Ph.D. with honors in 2009. His scientific career has focused on evaluating the anti-carcinogenic, anti-inflammatory, and neuroprotective activities&nbsp;</span><span lang="EN-US" dir="ltr">of different dietary polyphenols and their in vivo metabolites under physiological conditions, in both preclinical (cell and animal models) and clinical studies, thus evaluating whether polyphenols contribute, at least in part, to the correlation between a diet rich in fruits and vegetables and a lower incidence of chronic diseases. He is author/co-author of more than 100 scientific research publications with a H-index of 52.</span><span lang="EN-GB" dir="ltr"> Remarkably, the impact of his research led to his recognition as a highly-cited researcher in 2020 and 2021 (Clarivate, Web of Science).</span></p><p class="text-align-justify">&nbsp;</p><drupal-media data-entity-type="media" data-entity-uuid="afc0c2ab-7643-43c2-852f-33597bb6f8b9" data-align="center">&nbsp;</drupal-media><p><strong>Speaker: Antonio Gonzalez Sarrias </strong>(<em><span lang="EN-GB" dir="ltr">Tenured Scientist at CEBAS-CSIC (Murcia, Spain))<strong>&nbsp;</strong></span></em></p><p><strong>Sponsors: </strong>RCCHU; Harvard University; CEBAS-CSIC.</p>
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DTSTART:20250415T160000Z
DTEND:20250415T170000Z
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